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Scientific publications
Inhibitory and bactericidal effect of Artilysin® Art-175 against colistin- resistant mcr-1-positive Escherichia coli isolates
The number of mcr-1-positive isolates has increased tremendously since the first report of the plasmid-mediated colistin resistance mechanism [1]. Isolates with the transferable gene have been identified in (food) animals, various types of meat, vegetables and humans in more than 30 countries [2]. As a consequence, the Chinese government has forbidden the use of colistin as a growth promotor for the veterinary sector...
Breaking barriers: expansion of the use of endolysins as novel antibacterials against Gram-negative bacteria.
The emergence and spread of antibiotic-resistant bacteria drives the search for novel classes of antibiotics to replenish our armamentarium against bacterial infections...
From endolysins to Artilysin®s: novel enzyme-based approaches to kill drug-resistant bacteria.
One of the last untapped reservoirs in nature for the identification of new anti-microbials is bacteriophages, the natural killers of bacteria. Lytic bacteriophages encode peptidoglycan (PG) lytic enzymes able to degrade the PG layer in different steps of their infection cycle.
Efficacy of Artilysin® Art-175 against Resistant and Persistent Acinetobacter baumannii.
Bacteriophage-encoded endolysins have shown promise as a novel class of antibacterials with a unique mode of action, i.e., peptidoglycan degradation...
Engineered endolysin-based "Artilysins®" to combat multidrug-resistant gram-negative pathogens.
The global threat to public health posed by emerging multidrug-resistant bacteria in the past few years necessitates the development of novel approaches to combat bacterial infections...
Art-175 is a highly efficient antibacterial against multidrug-resistant strains and persisters of Pseudomonas aeruginosa.
Artilysin®s constitute a novel class of efficient enzyme-based antibacterials. Specifically, they covalently combine a bacteriophage-encoded endolysin, which degrades the peptidoglycan,...
'Artilysation' of endolysin λSa2lys strongly improves its enzymatic and antibacterial activity against streptococci.
Endolysins constitute a promising class of antibacterials against Gram-positive bacteria. Recently, endolysins have been engineered with selected peptides to obtain a new generation of lytic proteins, Artilysin®s, with specific activity against Gram-negative bacteria...