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Scientific publications

Inhibitory and bactericidal effect of Artilysin® Art-175 against colistin- resistant mcr-1-positive Escherichia coli isolates

The number of mcr-1-positive isolates has increased tremendously since the first report of the plasmid-mediated colistin resistance mechanism [1]. Isolates with the transferable gene have been identified in (food) animals, various types of meat, vegetables and humans in more than 30 countries [2]. As a consequence, the Chinese government has forbidden the use of colistin as a growth promotor for the veterinary sector...

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Breaking barriers: expansion of the use of endolysins as novel antibacterials against Gram-negative bacteria.

The emergence and spread of antibiotic-resistant bacteria drives the search for novel classes of antibiotics to replenish our armamentarium against bacterial infections...

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From endolysins to Artilysin®s: novel enzyme-based approaches to kill drug-resistant bacteria.

One of the last untapped reservoirs in nature for the identification of new anti-microbials is bacteriophages, the natural killers of bacteria. Lytic bacteriophages encode peptidoglycan (PG) lytic enzymes able to degrade the PG layer in different steps of their infection cycle.

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Efficacy of Artilysin® Art-175 against Resistant and Persistent Acinetobacter baumannii.

Bacteriophage-encoded endolysins have shown promise as a novel class of antibacterials with a unique mode of action, i.e., peptidoglycan degradation...

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Engineered endolysin-based "Artilysins®" to combat multidrug-resistant gram-negative pathogens.

The global threat to public health posed by emerging multidrug-resistant bacteria in the past few years necessitates the development of novel approaches to combat bacterial infections...

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Art-175 is a highly efficient antibacterial against multidrug-resistant strains and persisters of Pseudomonas aeruginosa.

Artilysin®s constitute a novel class of efficient enzyme-based antibacterials. Specifically, they covalently combine a bacteriophage-encoded endolysin, which degrades the peptidoglycan,...

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'Artilysation' of endolysin λSa2lys strongly improves its enzymatic and antibacterial activity against streptococci.

Endolysins constitute a promising class of antibacterials against Gram-positive bacteria. Recently, endolysins have been engineered with selected peptides to obtain a new generation of lytic proteins, Artilysin®s, with specific activity against Gram-negative bacteria...

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